A postdoctoral position is available to study function and regulation of proteins involved in intracellular signaling relevant to human disease, with emphasis on understanding them at a detailed molecular level. Methods could include cellular mechanistic studies (CRISPR, mutagenesis, transcriptional analysis, proteomics), biochemical and biophysical characterization of purified proteins or complexes, and use or discovery of chemical probes. The candidate would join a highly interdisciplinary group including molecular biologists, structural biologists, and chemists, and would have the opportunity to interact with a wide range of researchers at Genentech. Past work in the lab has explored ligand recognition in Wnt signaling (PMID: 20093360; 21944579), substrate recognition by the Polycomb E3 ubiquitin ligase RING1B/BMI1 (PMID:21772249; 26151332), and regulation of the deubiquitinase OTUD5/DUBA (PMID: 22245969; 25470037). More recent work has focused on bromodomain epigenetic "reader" modules (PMID: 26365797; 27056325; 27190605; 27219867; 27682507; 28606761; 28740608; 30289257; 31273347) and chromatin remodeling complexes (PMID: 29021563; 28801535).

Requirements:

Ph.D. in Biochemistry, Molecular Biology, or Chemistry, with significant research experience in protein structure-function studies. Must have strong molecular biology and protein purification skills. Experience in biophysical methods (calorimetry, SPR, etc.), enzymology, or structural techniques is highly desirable. Candidates with experience in epigenetic research (e.g., ChIP-seq and other chromatin methods, including experience in data analysis), transcriptional regulation, or acetylation biology are also welcome. Please apply for this job formally in our system and you can also send your CV (including names of three references) and cover letter to Andrea Cochran, Department of Early Discovery Biochemistry, Genentech, Inc. (cochran.andrea@gene.com).

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