Principle Scientist - Biotransformation
South San Francisco, CA 
Posted 1 month ago
Job Description
Career CategoryScientificJob Description

Amgen is seeking a highly motivated scientist to join the Pharmacokinetics & Drug Metabolism (PKDM) department at our site in South San Francisco, California. Amgen provides a collaborative and creative culture in a company with a strong track record of innovation. Our culture encourages open dialogue and diverse views to land on the best solutions, and we help ensure our staff are equipped to excel today and tomorrow.

The department of pharmacokinetics and drug metabolism (PKDM) within Amgen is dedicated to the discovery and development of novel effective, safe medicines. The successful candidate will work in a team environment to characterize the absorption, distribution, metabolism, excretion and pharmacokinetic properties of therapeutic drug candidates to achieve their full pharmacological potential. PKDM works in close partnership with disciplines such as medicinal chemistry, pharmacology, toxicology, pharmaceutical sciences, clinical pharmacology and regulatory to design promising clinical therapeutic candidates, conduct preclinical development studies, support clinical evaluation and contribute to IND and NDA filings.

Job Description

The Bio-transformation Principle Scientist leader will be in charge of implementing cutting edge separations and mass spectrometry tools (LC/MS) for the identification, quantitative and qualitative analysis of novel drug candidates and their metabolites from in vitro and in vivo biological matrices. The role will provide opportunity to work with broad range of scientific expertise and leadership across the Research organization. The role will broadly cover biotransformation of small molecules, proteins and RNAi therapeutics.

The ideal candidate will have a proven ability to design and execute experiments to conduct metabolite identification, isolation and characterization, have general understanding of enzyme kinetics, and understand clearance mechanism in support of both drug discovery and development programs. This role requires an excellent understanding of preclinical in vivo models, in vitro ADME and bioanalytical techniques. This role is ideally suited for an individual that can work collaboratively in a fast-paced work environment. The candidate should also assist in new technology, strategies, and data processing implementation. Other responsibilities/opportunities will include writing scientific reports, author original scientific manuscripts and present results to project teams or at scientific meetings.

Basic Qualifications

Doctorate degree and 3 years of Scientific experience
Master's degree and 6 years of Scientific experience
Bachelor's degree and 8 years of Scientific experience

Preferred Qualifications

  • PhD or MS in chemistry, biochemistry, or equivalent.
  • Experience with operation, troubleshooting, and data interpretation of a mass spectrometer is required.
  • Experience with operation of automated liquid sample handling instruments and experience with analysis of radiolabeled compounds is desired.
  • The candidate should possess excellent oral and written communication skills and be able to excel in a highly collaborative, matrixed team environment.
  • Interactions and collaboration with academic and other external scientists are encouraged.

We understand that to successfully sustain and grow as a global enterprise and deliver for patients - we must ensure a diverse and inclusive work environment.

Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology.

Amgen focuses on areas of high unmet medical need and leverages its expertise to strive for solutions that improve health outcomes and dramatically improve people's lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the world's leading independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential.

Join Us

If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.


Job Summary
Start Date
As soon as possible
Employment Term and Type
Regular, Full Time
Required Education
Bachelor's Degree
Required Experience
3+ years
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