Director - Translational ADME
South San Francisco, CA 
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Posted 1 month ago
Job Description
Career CategoryScientificJob Description

Amgen is seeking a highly motivated scientist to join the Pharmacokinetics & Drug Metabolism (PKDM) department at our site in South San Francisco, California. Amgen strives to serve patients by transforming the promise of science and biotechnology into therapies that have the power to restore health and save lives. Our culture encourages open dialogues and diverse views to create and innovate ideas to solve the critical issues in drug discovery and development.

The department of pharmacokinetics and drug metabolism (PKDM) within Amgen is dedicated to the discovery and development of novel effective, safe medicines. The successful candidate will work in a team environment to characterize the absorption, distribution, metabolism, excretion and pharmacokinetic (ADME) properties of therapeutic drug candidates to achieve their full pharmacological potential. PKDM works in close partnership with disciplines such as medicinal chemistry, pharmacology, toxicology, pharmaceutical sciences, clinical pharmacology and regulatory to design promising clinical therapeutic candidates, conduct preclinical development studies, support clinical evaluation and contribute to IND and NDA filings.

In this role, your core responsibilities are to:

  • Drive the progression of discovery and development project teams
  • Lead PKDM efforts for IND and NDA/BLA filings
  • Lead development of scientific strategy across PKDM initiatives
  • Evaluate and implement novel technologies to characterize the disposition of new chemical entities
  • Work closely with business development group to evaluate external opportunities
  • Develop and mentor direct staff
  • Build close relationships with partner functions and therapeutic areas


In addition to the core responsibilities, the position provides the opportunity to pursue scientific inquiries into the fundamental physiological and biochemical factors that determine the absorption, distribution, and clearance of protein and other emerging therapeutics. A collaborative and highly capable scientific community at Amgen is available to support these efforts. Interactions and collaboration with academic and other external scientists are highly encouraged.

Basic Qualifications

Doctorate degree and 4 years of Scientific experience
OR
Master's degree and 7 years of Scientific experience
OR
Bachelor's degree and 9 years of Scientific experience

Preferred Qualifications

  • PhD or MS in chemistry, biochemistry, or equivalent.
  • The ideal candidate will have a proven track record with regulatory submissions, experience integrating PK/PD and modeling and simulation, familiarity with multiple therapeutic modalities, and strong external eminence (publishing).
  • This role requires an excellent understanding of preclinical ADME and the factors influencing drug disposition, as well as an individual that can work collaboratively in a highly matrixed environment.

We understand that to successfully sustain and grow as a global enterprise and deliver for patients - we must ensure a diverse and inclusive work environment.

Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology.

Amgen focuses on areas of high unmet medical need and leverages its expertise to strive for solutions that improve health outcomes and dramatically improve people's lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the world's leading independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential.

Join Us

If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.

 

Job Summary
Company
Start Date
As soon as possible
Employment Term and Type
Regular, Full Time
Required Education
Bachelor's Degree
Required Experience
4+ years
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