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We are seeking a highly motivated postdoctoral research fellow who has a strong interest in and the essential skills for studying T cells in immune regulation to join the Kim lab in the Department of Immunology at Genentech. You will work closely with a diverse scientific team including neuroscientists, oncologists, and bioinformaticians.

The Opportunity:

• Lead projects that advance our understanding of the cellular and molecular mechanisms of T cell biology in inflammation and autoimmunity, with a main emphasis on tissue specific function of regulatory T cells for reestablishing immune homeostasis.

• Mechanisms of restoration of tissue homeostasis in T cell mediated autoimmunity.

• Identification of key molecular events of regulatory T cells that control autoinflammation and tissue damage using mouse model of autoimmune disease.

• The scientific insights obtained from this project are expected to be published in high impact journals and furthermore provide the basis for therapeutic opportunities for autoimmune disorders such as Multiple Sclerosis.

Who You Are:

• PhD in Immunology, Molecular Biology, Cell Biology or related biological science

• Passion in tracking complex biological problems and vigorous scientific logics are desired.

• Strong scientific background that could include cellular and molecular Immunology, multi-dimensional flowcytometry and in vivo animal models

• Excellent skills in communication, scientific curiosity and track record in a highly collaborative environment

Relevant Publications:

1. Kim HJ, Barnitz RA, Kreslavsky T, Brown FD, Moffett H, Lemieux ME, Kaygusuz Y, Meissner T, Holderried T, Chan S, Kastner P, Haining WN, Cantor H. (2015) Stable inhibitory activity of regulatory T cells requires the transcription factor Helios. Science Oct 16. Vol 350 Issue 6258: 334-339.

2. Nakagawa H, Sido JM, Reyes EE, Kiers V, Cantor H*, Kim HJ*. (2016) Instability of Helios-deficient Treg is associated with conversion to a T-effector phenotype and enhanced anti-tumor immunity. PNAS May 31;113(22):6248-53. (*co-senior authors)

3. Goel S, DeCristo M, Watt A, BrinJones H, Sceneay J, Li B, Khan N, Ubellacker J, Xie S, Metger O, Ma C, Hoog J, Ellis M, Ramm S, Krop I, Winer E, Roberts T, Kim HJ*, McAllister S*, Zhao J*. (2017) CDK4/6 inhibition promotes anti-tumor immunity by suppressing DNMT1. Nature 548, 471-475 (*co-senior authors)

4. Yates K, Bi K, Haining WN, Cantor H*, Kim HJ*. (2018) Comparative transcriptome analysis reveals distinct genetic modules associated with Helios expression in intratumoral regulatory T cells. PNAS. Feb 27;115(9):2162-2167 (*co-senior authors)

5. Kim HJ, Nakagawa H, Choi JY, Che X, Divris A, Liu Q, Wight A, Zhang H, Saad A, Solhjou Z, Deban C, Azzi J, Cantor H. (2023) A narrow T cell receptor repertoire instructs thymic differentiation of MHC class Ib-restricted CD8+ regulatory T-cells. J Clin Invest. 2023 Nov 7:e170512

Postdoc Program

Elevate your research career to new heights with Genetech's Postdoctoral Program! Join a prestigious community of early career scientists and kick-start your journey toward becoming a scientific leader in biotechnology and bioengineering. With competitive salaries and fully funded research expenses, you can dedicate yourself to groundbreaking research that aligns with Genentech strategic ambitions.

The postdoc program is designed to empower recent Ph.D. graduates to conduct world-class research, publish in top-tier journals, and build a robust scientific network. By joining us, you will receive the mentorship and support necessary to develop into an independent scientist and leader.

The provides access to world-class seminars, professional development workshops, and networking opportunities. Apply now to Genentech Postdoctoral Program and unlock your full potential!

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