Research Scientist - Purification and Assay Development

Temporary Assignment Through Outside Agency - Approximately 3-6 months

Approximately 40 Hours Per Week

Job #24-04AT

Mapp Biopharmaceutical, Inc. "Mapp" is a San Diego based, innovative biopharmaceutical company focused on addressing unmet medical needs through the development of life-saving monoclonal antibody treatment options to combat a variety of neglected and tropical infectious diseases, and in support of biodefense programs.

The Early Research and Development Group (ERDG) and the Advanced Research and Development Group (ARDG) at Mapp Biopharmaceutical are responsible for the execution of high quality Research and Development activities to ensure the achievement of a robust portfolio through CMC, Nonclinical, Regulatory, Project Management, and Clinical activities consistent with Mapp's product development objectives.

The Research Scientist, Purification and Assay Development reports into the ARDG group at Mapp and is responsible for designing and executing the purification and assay development laboratory activities for various therapeutic antibody candidates, biotherapeutics, and protein antigens produced across several different expression platforms from Discovery to Development. The Research Scientist, Purification and Assay Development has demonstrated significant laboratory and independent contributor activities in a discipline and can design, execute, and analyze experiments in the required technical area across existing and future programs.

Basic Qualifications

• PhD or equivalent in a related scientific discipline
• 2+ years of experience in a development research laboratory doing related work
• Hands-on experience with protein/antibody purification (affinity, IEX, SEC, etc.) using the AKTA and Agilent HPLC systems
• Experience in assessing chromatography resins, techniques and/or methodologies to optimize protein purification workflows
• Hands-on experience in protein/antibody characterization using various analytical techniques, including Nanodrop, SDS-PAGE, ELISA, qPCR, and bead-based assays
• Experience with the standard protein/antibody analytical methods used for QC, batch release, stability
• Experience in analytical and bio-analytical method development for proteins/antibodies
• Experience with mammalian cell suspension cultures such as Chinese Hamster Ovary (CHO) and primary B/T cells
• Excellent aseptic/sterile technique
• Experience writing methods, SOPs, and BRs
• Experience in managing process and method transfers to process development and manufacturing teams
• Demonstrated rigor around documentation of experimental plans, execution, and reporting
• Ability to work independently and effectively troubleshoot experimental strategies in the laboratory
• Attention to detail

Preferred Qualifications

• Hands-on experience with the Beacon platform and Beacon antibody discovery and clonal cell line assays is highly preferred
• Experience in taking biochemical and cell-based assays from bench to automation and use of liquid handler systems (Bravo, Tecan, etc.)
• In-depth knowledge in protein biochemistry and biochemical assay development

Responsibilities

• Executes purification, assay and method development for proteins/antibodies and antibody-like candidates coming either from Mapp Discovery or from external sources
• Supports upstream, downstream and analytical teams at Mapp by implementing, optimizing, and pre-validating quantitative methods for characterization of cell culture supernatants and antibodies/proteins
• Supports upstream, downstream and analytical teams at Mapp by implementing, optimizing, and pre-validating transfer of bench assays to automated format
• Collaborates with ARDG process and analytical scientists to incorporate new platform downstream processes and analytical methods into on-going and future studies
• Utilizes established processes and methods to purify and characterize material from antibody or antibody-like leads to a suitable level to support further process and method optimization
• Ensures documentation of new methods and processes is sufficiently robust for transfer to departments within Mapp and outside vendors
• Cross-trains other analysts in newly established purification and analytical methods and processes
• Participates in the maturation of the pilot-scale production, downstream purification, analytical, and preformulation capability within Mapp
• Provides clear, concise data summaries suitable for the intended audiences

Mapp's anticipated pay scale for this position is $50.49 per hour ($105,000 annualized) to $67.31 per hour ($140,000 annualized). The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the candidate's level of education, and type and length of experience within the job and/or within the industry.

This position is an on-site position located in Mapp's new state-of-the-art San Diego facility.

Mapp invites you to apply by submitting your information through . This job will remain open for twenty (20) days after being posted on Mapp's Job Openings website page (see link).

No Solicitors, agents or placement agencies please. Mapp utilizes E-Verify.

Mapp is an Equal Opportunity/Affirmative Action/Disability/Veterans Employer - Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected Veteran status, or any other characteristic protected by applicable federal, state, or local law.