The Assistant Project Scientist (APS) makes significant and creative contributions to a research or creative project in his/her academic discipline. The appointee possesses the subject matter expertise and the creative energy necessary to function at a high level of competence. The appointee will participate in activities to increase, improve, or upgrade competency. Appointees with Project (e.g., Scientist) titles may engage in University and public service. Although the APS is expected to work independently under the general guidance of an academic member with an independent research program (i.e., Professor, Professional Researcher, Specialist in Cooperative Extension, etc), he/she is not required to develop an independent research program or reputation. He/she will carry out research or creative programs with supervision by an individual in an academic title that carries with it automatic Principal Investigator status. The APS does not usually serve as a Principal Investigator but may do so by exception.

RESEARCH (90%)

Working for faculty member David Segal, the APS will be expected to investigate therapeutic approaches to neurologic disease, particularly Neurofibromatosis and ADNP syndromes. The APS will be expected to examine gene expression changes in iPSC-derived human neuronal cell cultures in response to various molecular treatments, such as epigenetic editing with CRISPR or zinc finger, or with antisense oligonucleotides.

The APS will also interact with other members of the Segal laboratory and with Segal laboratory collaborators on various collaborative projects. The incumbent will prepare drafts of all manuscripts that relate to his/her research project(s), and is expected to help in the mentoring and training of undergraduate and graduate students and other members of the Segal laboratory, including instruction on molecular biology, cell culture, statistical data and image analyses. The candidate is expected to assist with activities needed to maintain the lab. The APS will perform management and leadership tasks, including but not limited to providing technical assistance when needed, overseeing the ordering of supplies, and facilitating lab meetings as needed.

PROFESSIONAL COMPETENCE AND ACTIVITY (5%)

The APS will participate in professional societies and conferences appropriate to their specific field. The incumbent will attend seminars to present research results and may give oral presentations to public and professional interest groups. The APS may coordinate and/or give presentations at seminars, laboratory meetings or educational functions.

UNIVERSITY AND PUBLIC SERVICE (5%)

The APS will engage in public outreach activities that include presenting scientific research results to the general public. The candidate may engage in University service activities such as guest lecturing, committee service, voting on peer committees.

* PhD degree level in molecular biology, genetics, neuroscience or related field.
* A minimum of 5 years of research experience in molecular therapy of rare disorders.
* Extensive knowledge of the growth of maintenance of human neural progenitor cells and differentiated neurons, including maintaining, cryogenic storing, differentiating, characterizing, co-culturing, differentiating, and introducing. DNA/RNA/protein by electroporation, transfection, or viral vector transduction.
* A minimum of 5 years of experience with molecular cloning and viral vector preparation.
* A minimum of 5 years of experience with RT-qPCR, flow cytometry, and immunocytochemistry.
* Experience growing human neurons on multi-electrode array (MEA) chips.
* Experience mentoring both undergraduate and graduate scholars.
* Experience in leading a team of trainees and technical staff.

• 3 required (contact information only)

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