Sr. Research Associate II (In situ applications)
Pleasanton, CA 
Posted 1 month ago
Job Description

About the role:

We're in search of an exceptional Research Associate to join our Spatial Team. You'll be an integral part of our highly collaborative R&D team, focused on demonstrating the value of 10x products. As a research associate, you will be responsible for performing the in situ analysis of biological tissue samples from collaborators and customer projects. This will involve supporting all aspects of the process, from library preparation, instrument operation, and initial analysis and QC of the data, ensuring the highest quality results are achieved throughout the entire process. The successful candidate in this position will work closely with expert scientists in spatial analysis and will have the opportunity to participate in high profile cutting edge biological and disease-related research projects.

You bring a strong background in the biological sciences and have acquired significant experience in conducting in situ and spatial genomic assays. You possess excellent communication skills, are detail oriented and can effectively collaborate with interdisciplinary teams, integrating their feedback into your experimental design. Your high motivation, proactiveness, and adaptability allow you to navigate changing priorities and methods with ease. Thriving in fast-paced environments, you excel at managing multiple priorities, communicating clearly, and consistently delivering results.

What you will be doing:

  • Performing in situ assays on tissue sections on microscope glass slides
  • High throughput fluorescent microscopy imaging of the processed tissue samples, and image data pre-processing
  • Library preparation workflows
  • Participate in troubleshooting of assays and microscope instruments
  • Optimization studies of protocols for specific tissue samples
  • Deliver processed image data to and work closely with computational biologists for image data analysis
  • Maintain relevant documentation for record keeping related to the projects

To be successful, you will need:

  • MSc, or equivalent, in Biomedical Sciences, Molecular Biology, Biochemistry, or a related field
  • Experience with molecular biology techniques including immunostaining and/or in situ hybridization techniques (e.g. FISH, RNAscope, in situ hybridization)
  • A proven track-record of using and optimizing and troubleshooting molecular biology protocols
  • Light and fluorescent microscopy experience (confocal or standard epi-fluorescence)
  • Knowledge and troubleshooting experience with liquid handling or automated systems (e.g. Tecan, Hamilton)

Additionally, we'd like to see:

  • Tissue handling experience (fresh frozen, FFPE, cryosectioning, antigen retrieval, etc.)
  • Strong organizational skills and ability to plan and structure your work
  • Excellent interpersonal skills, including written and oral communication
  • Ability to work in a fast-paced and quickly changing environment

It would be advantageous if you had:

  • Basic coding skills
  • Experience with image analysis using relevant SW (e.g. CellProfiler, ImageJ)
  • Familiarity with NGS library preparation workflows
  • Work experience from similar positions in academia, industry or a service provider/core facility

Below is the base pay range for this full time position. The actual base pay will depend on several factors unique to each candidate, including one's skills, qualifications, and experience. At 10x, base pay is also just one component of the Company's total compensation package. This role is also eligible for 10x's equity grants, its comprehensive health and retirement benefit programs, and its annual bonus program or sales incentive program. Your 10x recruiter can share more about the Company's total compensation package during the hiring process.

Pay Range
$100,000$136,000 USD

About 10x Genomics

At 10x Genomics, accelerating our understanding of biology is more than a mission for us. It is a commitment. This is the century of biology, and the breakthroughs we make now have the potential to change the world.

We enable scientists to advance their research, allowing them to address scientific questions they did not even know they could ask. Our tools have enabled fundamental discoveries across biology including cancer, immunology, and neuroscience.

Our teams are empowered and encouraged to follow their passions, pursue new ideas, and perform at their best in an inclusive and dynamic environment. We know that behind every scientific breakthrough, there is a deep infrastructure of talented people driving the life sciences industry and making it possible for scientists and clinicians to make new strides. We are dedicated to finding the very best person for every aspect of our work because the innovations and discoveries that we enable together will lead to better technologies, better treatments, and a better future. Find out how you can make a 10x difference.

Individuals seeking employment at 10x Genomics are considered without regards to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation,or any other characteristic protected by applicable law.

10x does not accept unsolicited applicants submitted by third-party recruiters or agencies. Any resume or application submitted to 10x without a vendor agreement in place will be considered unsolicited and property of 10x, and 10x will not pay a placement fee.


Job Summary
Start Date
As soon as possible
Employment Term and Type
Regular, Full Time
Required Experience
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